About Enhancer
| Enhancer ID: | E_03114 |
| Species: | Homo sapiens |
| Position : | chr11:17666830-17677080   |
| Year: | 2017 |
| Title: | PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | alveolar rhabdomyosarcoma |
| PMID: | 28446439 |
| MONDO: | MONDO:0009994 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Human Fibroblast Cell Lines |
| Cell Type: | fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | MYOD1 |
About TF
| TF name : | PAX3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX3 | HATs acetylate histones | reactome | 142 |
| PAX3 | Regulation of retinoblastoma protein | pid | 67 |
| PAX3 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| PAX3 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03113 | chr11:17666830-17677080 | blood / hematopoietic system | fibroblast | alveolar rhabdomyosarcoma |
Expression of Target Genes for the Enhancer