About Enhancer
| Enhancer ID: | E_03124 |
| Species: | Homo sapiens |
| Position : | chr21:39823183-39825183   |
| Year: | 2011 |
| Title: | ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 21536859 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | T-acute lymphoblastic leukemia (T-ALL),Molt4,REH,416B |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | ERG |
About TF
| TF name : | LYL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| LYL1 | Hs_TYROBP_Causal_Network_WP3945_90843 | wikipathways | 54 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03098 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03099 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03100 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03101 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03102 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03103 | chr21:39823183-39825183 | blood | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03122 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03123 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03125 | chr21:39823183-39825183 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_03148 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03149 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03150 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03151 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03152 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03153 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03154 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
| E_03155 | chr21:39823183-39825183 | blood | NA | acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer