About Enhancer
| Enhancer ID: | E_03129 |
| Species: | Mus musculus |
| Position : | chr3:34668260-34668560   |
| Year: | 2011 |
| Title: | Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 21331042 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic stem |
| CVCL ID: | |
| Cell Type: | mouse embryonic stem cell |
| Cell Ontology ID: | CL:0002322 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | |
| Low Throughput Method: | Transgenic Reporter Assay, CRISPR Knockout, EMSA, in situ Hybridization, Immunohistochemistry |
About Target Gene
| Target gene : | Sox2 |
About TF
| TF name : | Lef1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Lef1 | Alzheimer disease-presenilin pathway | panther | 98 |
| Lef1 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| Lef1 | C-MYB transcription factor network | pid | 87 |
| Lef1 | Ca2+ pathway | reactome | 62 |
| Lef1 | Cadherin signaling pathway | panther | 147 |
| Lef1 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Lef1 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Lef1 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Lef1 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Lef1 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Lef1 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Lef1 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Lef1 | Integrin-linked kinase signaling | pid | 46 |
| Lef1 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Lef1 | Notch | netpath | 76 |
| Lef1 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Lef1 | Repression of WNT target genes | reactome | 14 |
| Lef1 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Lef1 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Lef1 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Lef1 | TGF_beta_Receptor | netpath | 220 |
| Lef1 | Wnt | netpath | 118 |
| Lef1 | Wnt signaling pathway | panther | 250 |
| Lef1 | Wnt signaling pathway | kegg | 135 |
| Lef1 | Adherens junction | kegg | 70 |
| Lef1 | Melanogenesis | kegg | 100 |
| Lef1 | Pathways in cancer | kegg | 321 |
| Lef1 | Colorectal cancer | kegg | 63 |
| Lef1 | Endometrial cancer | kegg | 52 |
| Lef1 | Prostate cancer | kegg | 85 |
| Lef1 | Acute myeloid leukemia | kegg | 53 |
| Lef1 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| Lef1 | Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571 | wikipathways | 28 |
| Lef1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Lef1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer