About Enhancer
| Enhancer ID: | E_03134 |
| Species: | Mus musculus |
| Position : | chr2:155134800-155135200   |
| Year: | 2020 |
| Title: | Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 32290491 |
| MONDO: | |
| Tissue: | Cartilage |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | ATDC5 Chondrogenic |
| CVCL ID: | CVCL_3894 |
| Cell Type: | chondrocyte |
| Cell Ontology ID: | CL:0000138 |
| Experiment Type: | TF binding assay, Functional perturbation assay |
| High Throughput Method: | CAGE, ChIP-seq, RNA-seq, Microarray |
| Low Throughput Method: | ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | Hck |
About TF
| TF name : | Runx2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx2 | AndrogenReceptor | netpath | 167 |
| Runx2 | FGF signaling pathway | pid | 55 |
| Runx2 | Leptin | netpath | 98 |
| Runx2 | Notch-mediated HES/HEY network | pid | 48 |
| Runx2 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx2 | Regulation of retinoblastoma protein | pid | 67 |
| Runx2 | TGF_beta_Receptor | netpath | 220 |
| Runx2 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Runx2 | Hs_MAPK_Signaling_Pathway_WP382_79951 | wikipathways | 58 |
| Runx2 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Runx2 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Runx2 | Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 | wikipathways | 6 |
| Runx2 | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03133 | chr2:155134800-155135200 | Cartilage | chondrocyte | -- |
Expression of Target Genes for the Enhancer