About Enhancer
| Enhancer ID: | E_03144 |
| Species: | Mus musculus |
| Position : | chr14:75355955-75357027   |
| Year: | 2007 |
| Title: | Transcriptional Control of Receptor Activator of Nuclear Factor-B Ligand by the Protein Kinase A Activator Forskolin and the Transmembrane Glycoprotein 130-Activating Cytokine, Oncostatin M, Is Exerted through Multiple Distal Enhancers |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 17053039 |
| MONDO: | |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | |
| CVCL ID: | |
| Cell Type: | |
| Cell Ontology ID: | |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase reporter assay, ChIP-RT-qPCR, qRT-PCR, EMSA |
About Target Gene
| Target gene : | Tnfsf11 |
About TF
| TF name : | Creb1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Creb1 | AKT phosphorylates targets in the nucleus | reactome | 9 |
| Creb1 | AndrogenReceptor | netpath | 167 |
| Creb1 | AP-1 transcription factor network | pid | 71 |
| Creb1 | ATF-2 transcription factor network | pid | 59 |
| Creb1 | BCR | netpath | 161 |
| Creb1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| Creb1 | CaMK IV-mediated phosphorylation of CREB | reactome | 5 |
| Creb1 | Circadian Clock | reactome | 49 |
| Creb1 | Constitutive Signaling by AKT1 E17K in Cancer | reactome | 25 |
| Creb1 | CREB phosphorylation | reactome | 7 |
| Creb1 | CREB phosphorylation through the activation of Adenylate Cyclase | reactome | 7 |
| Creb1 | CREB phosphorylation through the activation of CaMKII | reactome | 17 |
| Creb1 | CREB phosphorylation through the activation of CaMKK | reactome | 6 |
| Creb1 | CREB phosphorylation through the activation of Ras | reactome | 13 |
| Creb1 | EGFR1 | netpath | 475 |
| Creb1 | Enkephalin release | panther | 17 |
| Creb1 | ErbB1 downstream signaling | pid | 105 |
| Creb1 | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | smpdb | 7 |
| Creb1 | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | smpdb | 7 |
| Creb1 | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | smpdb | 7 |
| Creb1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Creb1 | FSH | netpath | 44 |
| Creb1 | Gastrin-CREB signalling pathway via PKC and MAPK | reactome | 9 |
| Creb1 | Glucocorticoid receptor regulatory network | pid | 85 |
| Creb1 | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | panther | 126 |
| Creb1 | Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) ( GPCR Adenosine A2A receptor signaling pathway ) | inoh | 9 |
| Creb1 | Heterotrimeric GPCR signaling pathway (through Dopamine and G alpha s) ( GPCR Dopamine D1like receptor signaling pathway ) | inoh | 45 |
| Creb1 | HIF-1-alpha transcription factor network | pid | 67 |
| Creb1 | IL2 | netpath | 81 |
| Creb1 | IL3 | netpath | 84 |
| Creb1 | Integrin-linked kinase signaling | pid | 46 |
| Creb1 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | smpdb | 37 |
| Creb1 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | smpdb | 38 |
| Creb1 | Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone | smpdb | 10 |
| Creb1 | Intracellular Signalling Through Histamine H2 Receptor and Histamine | smpdb | 8 |
| Creb1 | Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin | smpdb | 10 |
| Creb1 | Leptin | netpath | 98 |
| Creb1 | LKB1 signaling events | pid | 43 |
| Creb1 | LPA4-mediated signaling events | pid | 16 |
| Creb1 | NCAM signaling for neurite out-growth | reactome | 22 |
| Creb1 | Nongenotropic Androgen signaling | pid | 31 |
| Creb1 | NOTCH2 intracellular domain regulates transcription | reactome | 12 |
| Creb1 | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| Creb1 | RANKL | netpath | 84 |
| Creb1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Creb1 | Signaling events regulated by Ret tyrosine kinase | pid | 39 |
| Creb1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Creb1 | TCR | netpath | 261 |
| Creb1 | TNFalpha | netpath | 274 |
| Creb1 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| Creb1 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| Creb1 | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| Creb1 | TSH | netpath | 82 |
| Creb1 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Creb1 | VEGFR3 signaling in lymphatic endothelium | pid | 26 |
| Creb1 | Antigen processing and presentation | kegg | 75 |
| Creb1 | Melanogenesis | kegg | 100 |
| Creb1 | Vasopressin-regulated water reabsorption | kegg | 35 |
| Creb1 | Huntington's disease | kegg | 182 |
| Creb1 | Prostate cancer | kegg | 85 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer