About Enhancer
| Enhancer ID: | E_03169 |
| Species: | Homo sapiens |
| Position : | chrX:106960488-106960865   |
| Year: | 2018 |
| Title: | Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer-promoter contacts. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 29385519 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A-549 |
| CVCL ID: | CVCL_0023 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | GR-bound GILZ/TSC22D3 GBS1 enhancer interval; endogenous deletion and cell-type-specific wiring; Endogenous enhancer perturbation |
| High Throughput Method: | GR ChIP-seq; 4C-seq; Hi-C integration |
| Low Throughput Method: | CRISPR/Cas9 GR-binding-site deletion; qPCR; CTCF ChIP-qPCR; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | TSC22D3 |
About TF
| TF name : | NR3C1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR3C1 | AndrogenReceptor | netpath | 167 |
| NR3C1 | AP-1 transcription factor network | pid | 71 |
| NR3C1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| NR3C1 | Cellular roles of Anthrax toxin | pid | 25 |
| NR3C1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| NR3C1 | Glucocorticoid receptor regulatory network | pid | 85 |
| NR3C1 | IL2 | netpath | 81 |
| NR3C1 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR3C1 | PTK6 Expression | reactome | 5 |
| NR3C1 | Regulation of Androgen receptor activity | pid | 54 |
| NR3C1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| NR3C1 | Signaling events mediated by HDAC Class II | pid | 58 |
| NR3C1 | Neuroactive ligand-receptor interaction | kegg | 272 |
| NR3C1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| NR3C1 | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| NR3C1 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| NR3C1 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
| NR3C1 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03168 | chrX:106959618-106962917 | NA | NA | NA |
Expression of Target Genes for the Enhancer