About Enhancer
| Enhancer ID: | E_03174 |
| Species: | Homo sapiens |
| Position : | chr6:45333183-45333484   |
| Year: | 2025 |
| Title: | Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute lymphoblastic leukemia |
| PMID: | 40729681 |
| MONDO: | MONDO:0004967 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary human KMT2A::AFF1 ALL blast |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | scMultiome ATAC+RNA; H3K27ac CUT&Tag; Micro-Capture-C; single-cell multiome; Micro Capture-C; chromatin profiling |
| Low Throughput Method: | CRISPR enhancer deletion; RT-qPCR |
About Target Gene
| Target gene : | RUNX2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer