About Enhancer
| Enhancer ID: | E_03181 |
| Species: | Homo sapiens |
| Position : | chr10:63525013-63527013   |
| Year: | 2019 |
| Title: | The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 31076442 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer RNA assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; chromatin-interaction profiling; transcriptomic profiling |
| Low Throughput Method: | ARIEL shRNA knockdown; ChIP-qPCR; chromatin-interaction validation; RT-qPCR; cell-growth assay; xenograft assay |
About Target Gene
| Target gene : | ARID5B |
About TF
| TF name : | GATA3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA3 | C-MYB transcription factor network | pid | 87 |
| GATA3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| GATA3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA3 | Glucocorticoid receptor regulatory network | pid | 85 |
| GATA3 | IL27-mediated signaling events | pid | 26 |
| GATA3 | Notch signaling pathway | pid | 58 |
| GATA3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| GATA3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| GATA3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03180 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_03182 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_04041 | chr10:63525013-63527013 | blood / hematopoietic system | malignant cell | T-cell acute lymphoblastic leukemia |
| E_04096 | chr10:63525013-63527013 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer