About Enhancer
| Enhancer ID: | E_03208 |
| Species: | Homo sapiens |
| Position : | chr11:5280255-5281665   |
| Year: | 2015 |
| Title: | Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26501517 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Gene expression assay; Chromatin-state assay; Endogenous enhancer perturbation |
| High Throughput Method: | RNA-seq; H3K9me3 ChIP-seq; DNase-seq |
| Low Throughput Method: | dCas9-KRAB CRISPRi; RT-qPCR; H3K9me3 ChIP-qPCR; GATA2/FOSL1 ChIP-qPCR; Western blot; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03209 | chr11:5280255-5281665 | blood | malignant cell | NA |
Expression of Target Genes for the Enhancer