About Enhancer
| Enhancer ID: | E_03214 |
| Species: | Homo sapiens |
| Position : | chr11:27725730-27726223   |
| Year: | 2024 |
| Title: | An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 38228888 |
| MONDO: | MONDO:0011122 |
| Tissue: | brainstem |
| Tissue Ontology ID: | UBERON:0002298 |
| Cell Source: | Cranial motor neurons |
| Cell Type: | motor neuron |
| Cell Ontology ID: | CL:0000100 |
| Experiment Type: | Enhancer activity assay; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | GWAS; eQTL analysis |
| Low Throughput Method: | Luciferase Reporter Assay, qRT-PCR; CRISPR-Cas9 endogenous deletion/editing; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | BDNF |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer