Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03216
Species: Mus musculus
Position : chr6:6770399-6771465
Year: 2011
Title: Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
Disease Name: --
PMID:  20878775
MONDO:
Tissue: Skeletal muscle
Tissue Ontology ID: UBERON:0001134
Cell Source: C2C12 cells
CVCL ID: CVCL_0188
Cell Type: myoblast
Cell Ontology ID: CL:0000187
Experiment Type: Enhancer activity assay, TF binding assay, Chromatin interaction assay
High Throughput Method:
Low Throughput Method: Luciferase Reporter Assay, ChIP-RT-qPCR, GST Pull-down, Co-IP, RT-RT-qPCR, Western blot
About Target Gene
Target gene : Dlx5
About TF
TF name : Smad1; Smad4; Tcf4
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 3 found
Enhancer ID Position Tissue Cell Disease
E_03245 chr6:6770399-6771465 Skeletal muscle myoblast --
E_03246 chr6:6770399-6771465 Bone osteoblast --
E_03247 chr6:6770399-6771465 Bone marrow mesenchymal stem cell --
Expression of Target Genes for the Enhancer