About Enhancer
| Enhancer ID: | E_03226 |
| Species: | Homo sapiens |
| Position : | chr19:55417234-55417304   |
| Year: | 2012 |
| Title: | Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 22253448 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | NK-92 |
| CVCL ID: | CVCL_2142 |
| Cell Type: | natural killer cell |
| Cell Ontology ID: | CL:0000623 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase reporter assay; RUNX-site mutagenesis; EMSA; ChIP-qPCR; RT-qPCR; RT-PCR; Western blot |
About Target Gene
| Target gene : | NCR1 |
About TF
| TF name : | RUNX1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RUNX1 | AndrogenReceptor | netpath | 167 |
| RUNX1 | Organic cation transport | reactome | 9 |
| RUNX1 | RANKL | netpath | 84 |
| RUNX1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| RUNX1 | TGF_beta_Receptor | netpath | 220 |
| RUNX1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| RUNX1 | Pathways in cancer | kegg | 321 |
| RUNX1 | Chronic myeloid leukemia | kegg | 69 |
| RUNX1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03192 | chr19:55417234-55417304 | blood | natural killer cell | NA |
Expression of Target Genes for the Enhancer