About Enhancer
| Enhancer ID: | E_03230 |
| Species: | Homo sapiens |
| Position : | chr11:5301600-5302400   |
| Year: | 2015 |
| Title: | Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26501517 |
| Tissue: | blood / hematopoietic system |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Experiment Type: | TF-binding/chromatin assay; Endogenous enhancer perturbation |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | HBE1 |
About TF
| TF name : | TRIM28 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TRIM28 | ATM pathway | pid | 34 |
| TRIM28 | C-MYB transcription factor network | pid | 87 |
| TRIM28 | E2F transcription factor network | pid | 77 |
| TRIM28 | Generic Transcription Pathway | reactome | 358 |
| TRIM28 | p53 pathway | pid | 59 |
| TRIM28 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
28 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02356 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02363 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02364 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_02365 | chr11:5222500-5323700 | blood | erythroid cell | NA |
| E_03631 | chr11:5301485-5302895 | blood | malignant cell | NA |
| E_03231 | chr11:5301600-5302400 | blood / hematopoietic system | NA | NA |
| E_03232 | chr11:5301600-5302400 | blood / hematopoietic system | NA | NA |
| E_03070 | chr11:5301801-5302175 | pleural effusion | erythroid lineage cell | NA |
| E_03071 | chr11:5301801-5302175 | pleural effusion | erythroid lineage cell | NA |
| E_03200 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03201 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03202 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03203 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03204 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03205 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03206 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03207 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_03210 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03211 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03212 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_03213 | chr11:5301862-5302715 | blood | erythroid-like cell | NA |
| E_04277 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_04382 | chr11:5301862-5302715 | blood | malignant cell | NA |
| E_04567 | chr11:5301862-5302715 | blood | myeloid cell | NA |
| E_04237 | chr11:5301983-5302001 | pleural effusion | erythroid lineage cell | NA |
| E_04238 | chr11:5301983-5302001 | pleural effusion | erythroid lineage cell | NA |
| E_04245 | chr11:5301983-5302001 | uterine cervix | epithelial cell | NA |
| E_04246 | chr11:5301983-5302001 | uterine cervix | epithelial cell | NA |
Expression of Target Genes for the Enhancer