About Enhancer
| Enhancer ID: | E_03243 |
| Species: | Homo sapiens |
| Position : | chr22:39063777-39068917   |
| Year: | 2022 |
| Title: | B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell chronic lymphocytic leukemia |
| PMID: | 35778390 |
| MONDO: | MONDO:0004948 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MEC-1 |
| CVCL ID: | CVCL_1870 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | CUT&Tag; ATAC-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; CRISPRi; PCR validation; RT-qPCR; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | APOBEC3H |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03239 | chr22:39063777-39068917 | blood | B cell | B-cell chronic lymphocytic leukemia |
| E_03240 | chr22:39063777-39068917 | blood | B cell | B-cell chronic lymphocytic leukemia |
| E_03241 | chr22:39063777-39068917 | blood | B cell | B-cell chronic lymphocytic leukemia |
| E_03242 | chr22:39063777-39068917 | blood | B cell | B-cell chronic lymphocytic leukemia |
Expression of Target Genes for the Enhancer