About Enhancer
| Enhancer ID: | E_03247 |
| Species: | Homo sapiens |
| Position : | chr22:39094134-39100780   |
| Year: | 2022 |
| Title: | B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell chronic lymphocytic leukemia |
| PMID: | 35778390 |
| MONDO: | MONDO:0004948 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | MEC-1 |
| CVCL ID: | CVCL_1870 |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000236 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Endogenous enhancer perturbation |
| High Throughput Method: | CUT&Tag; ATAC-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; CRISPRi; PCR validation; RT-qPCR; Western blot; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | APOBEC3G |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
Expression of Target Genes for the Enhancer