About Enhancer
| Enhancer ID: | E_03254 |
| Species: | Mus musculus |
| Position : | chr3:2931-3443   |
| Year: | 2010 |
| Title: | c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-?|?? inhibits c-Maf-induced IL-21 production in CD4+ T cells |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell lymphoma |
| PMID: | 20042469 |
| MONDO: | MONDO:0005114 |
| Tissue: | Lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | EL4 |
| CVCL ID: | CVCL_0255 |
| Cell Type: | T lymphoma cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, Flow Cytometry, Coimmunoprecipitation |
About Target Gene
| Target gene : | Il21 |
About TF
| TF name : | C-Maf; Foxp3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer