About Enhancer
| Enhancer ID: | E_03270 |
| Species: | Homo sapiens |
| Position : | chr8:128000000-128300000   |
| Year: | 2016 |
| Title: | CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 26752646 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | CRC cells |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Super-enhancer functional analysis; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq; CRISPR screen |
| Low Throughput Method: | CRISPR perturbation; BET inhibition; expression assay; In vivo phenotyping |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | BRD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01136 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01137 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01138 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01139 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01140 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01141 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01816 | chr8:128132902-128133724 | kidney | malignant cell | renal cell carcinoma |
| E_01850 | chr8:128132902-128133724 | kidney | kidney proximal tubule epithelial cell | NA |
| E_03952 | chr8:128140000-128145000 | colon | malignant cell | colorectal cancer |
| E_04622 | chr8:128173203-128174158 | prostate gland | malignant cell | prostate cancer |
| E_02985 | chr8:128206162-128314310 | colon | NA | NA |
| E_02910 | chr8:128220000-128250000 | heart | cardiac muscle cell | NA |
| E_02916 | chr8:128220000-128250000 | blood | lymphoblastoid cell | NA |
| E_03391 | chr8:128230172-128243000 | colon | NA | colorectal cancer |
| E_01855 | chr8:128230503-128232194 | colon | epithelial cell | colorectal carcinoma |
| E_04578 | chr8:128296257-128297326 | NA | NA | NA |
| E_04577 | chr8:128299198-128301336 | NA | NA | NA |
Expression of Target Genes for the Enhancer