About Enhancer
| Enhancer ID: | E_03271 |
| Species: | Homo sapiens |
| Position : | chr2:233745300-233745811   |
| Year: | 2025 |
| Title: | Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 40301309 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | ShP51 (PXR-expressing HepG2 derivative) |
| Cell Type: | hepatocyte-like cell |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | CAGE; PXR/NR1I2 ChIP-seq (reprocessed primary human hepatocytes) |
| Low Throughput Method: | CRISPR/Cas9-mediated enhancer deletion; luciferase reporter assay; qRT-PCR; genotyping PCR; DNA sequencing |
About Target Gene
| Target gene : | UGT1A1 |
About TF
| TF name : | NR1I2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR1I2 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR1I2 | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer