About Enhancer
| Enhancer ID: | E_03275 |
| Species: | Homo sapiens |
| Position : | chr9:137494462-137494862   |
| Year: | 2024 |
| Title: | Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 38378865 |
| Tissue: | endometrium |
| Tissue Ontology ID: | UBERON:0001295 |
| Cell Source: | 1390C1 |
| CVCL ID: | CVCL_UP48 |
| Cell Type: | endometrial stromal cell |
| Experiment Type: | CRISPR interference (CRISPRi) |
| High Throughput Method: | lentiSTARR-seq, lentiMPRA, scATAC-seq; MPRA; whole-genome sequencing |
| Low Throughput Method: | RT-RT-qPCR; FACS; EMSA; Reporter assay |
About Target Gene
| Target gene : | COL5A1 |
About TF
| TF name : | SRF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SRF | Coregulation of Androgen receptor activity | pid | 61 |
| SRF | ErbB1 downstream signaling | pid | 105 |
| SRF | Interleukin signaling pathway | panther | 86 |
| SRF | p38 MAPK pathway | panther | 31 |
| SRF | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| SRF | PDGF signaling pathway | panther | 113 |
| SRF | PDGFR-alpha signaling pathway | pid | 22 |
| SRF | PDGFR-beta signaling pathway | pid | 125 |
| SRF | Ras Pathway | panther | 69 |
| SRF | RHO GTPases Activate Formins | reactome | 114 |
| SRF | RhoA signaling pathway | pid | 46 |
| SRF | Signaling events mediated by HDAC Class II | pid | 58 |
| SRF | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| SRF | MAPK signaling pathway | kegg | 264 |
| SRF | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| SRF | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| SRF | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SRF | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03273 | chr9:137494462-137494862 | endometrium | endometrial stromal cell | NA |
| E_03274 | chr9:137494462-137494862 | endometrium | endometrial stromal cell | NA |
| E_03276 | chr9:137494462-137494862 | endometrium | endometrial stromal cell | NA |
| E_03277 | chr9:137494462-137494862 | endometrium | endometrial stromal cell | NA |
Expression of Target Genes for the Enhancer