About Enhancer
| Enhancer ID: | E_03281 |
| Species: | Mus musculus |
| Position : | chr14:54000000-54000100   |
| Year: | 1991 |
| Title: | Cloning of Murine TCF-1, a T Cell-specific Transcription Factor Interacting with Functional Motifs in the CD3-E and T Cell Receptor alpha Enhancers |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 1827138 |
| MONDO: | |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | EL4 cells |
| CVCL ID: | CVCL_0255 |
| Cell Type: | T lymphoma cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | EMSA, Luciferase Reporter Assay |
About Target Gene
| Target gene : | Tcra |
About TF
| TF name : | Tcf7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Tcf7 | Angiogenesis | panther | 141 |
| Tcf7 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 |
| Tcf7 | Ca2+ pathway | reactome | 62 |
| Tcf7 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 |
| Tcf7 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Tcf7 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| Tcf7 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 |
| Tcf7 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Tcf7 | Repression of WNT target genes | reactome | 14 |
| Tcf7 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 |
| Tcf7 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 |
| Tcf7 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 |
| Tcf7 | Wnt signaling pathway | kegg | 135 |
| Tcf7 | Adherens junction | kegg | 70 |
| Tcf7 | Melanogenesis | kegg | 100 |
| Tcf7 | Pathways in cancer | kegg | 321 |
| Tcf7 | Colorectal cancer | kegg | 63 |
| Tcf7 | Endometrial cancer | kegg | 52 |
| Tcf7 | Prostate cancer | kegg | 85 |
| Tcf7 | Acute myeloid leukemia | kegg | 53 |
| Tcf7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| Tcf7 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03240 | chr14:54000000-54000100 | Lymph node | T lymphoma cell | T-cell lymphoma |
Expression of Target Genes for the Enhancer