About Enhancer
| Enhancer ID: | E_03290 |
| Species: | Homo sapiens |
| Position : | chr4:55568410-55569020   |
| Year: | 2018 |
| Title: | FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | gastrointestinal stromal tumor |
| PMID: | 29162563 |
| MONDO: | MONDO:0011719 |
| Tissue: | digestive tract |
| Tissue Ontology ID: | UBERON:0001555 |
| Cell Source: | GIST48 |
| CVCL ID: | CVCL_7041 |
| Cell Type: | interstitial cell of Cajal lineage |
| Experiment Type: | Enhancer occupancy assay; Pioneer-factor chromatin-accessibility assay; Functional perturbation assay |
| High Throughput Method: | FOXF1/ETV1/H3K4me1/H3K4me3 ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | KIT-enhancer ChIP-qPCR; FOXF1 siRNA knockdown; RT-qPCR; Western blot; cell-growth assay; xenograft assay |
About Target Gene
| Target gene : | KIT |
About TF
| TF name : | FOXF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXF1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03312 | chr4:55520000-55580000 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
| E_03287 | chr4:55568410-55569020 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
| E_03288 | chr4:55568410-55569020 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
| E_03289 | chr4:55568410-55569020 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
| E_03291 | chr4:55568410-55569020 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
| E_03292 | chr4:55568410-55569020 | digestive tract | interstitial cell of Cajal lineage | gastrointestinal stromal tumor |
Expression of Target Genes for the Enhancer