About Enhancer
| Enhancer ID: | E_03298 |
| Species: | Mus musculus |
| Position : | chr1:136179600-136180045   |
| Year: | 2017 |
| Title: | MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 28575289 |
| MONDO: | |
| Tissue: | Skeletal muscle |
| Tissue Ontology ID: | UBERON:0001134 |
| Cell Source: | C2C12 |
| CVCL ID: | CVCL_0188 |
| Cell Type: | myoblast |
| Cell Ontology ID: | CL:0000187 |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | Myog |
About TF
| TF name : | Foxo3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Foxo3 | AKT phosphorylates targets in the nucleus | reactome | 9 |
| Foxo3 | BCR | netpath | 161 |
| Foxo3 | Class I PI3K signaling events | pid | 46 |
| Foxo3 | Class I PI3K signaling events mediated by Akt | pid | 35 |
| Foxo3 | Constitutive Signaling by AKT1 E17K in Cancer | reactome | 25 |
| Foxo3 | FoxO family signaling | pid | 50 |
| Foxo3 | FSH | netpath | 44 |
| Foxo3 | IL-7 | netpath | 28 |
| Foxo3 | IL2 | netpath | 81 |
| Foxo3 | IL2 signaling events mediated by PI3K | pid | 38 |
| Foxo3 | IL3 | netpath | 84 |
| Foxo3 | IL5 | netpath | 59 |
| Foxo3 | IL6 | netpath | 85 |
| Foxo3 | Insulin Pathway | pid | 47 |
| Foxo3 | Insulin/IGF pathway-protein kinase B signaling cascade | panther | 22 |
| Foxo3 | Interleukin signaling pathway | panther | 86 |
| Foxo3 | KitReceptor | netpath | 104 |
| Foxo3 | MAPK6/MAPK4 signaling | reactome | 90 |
| Foxo3 | Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) ) | inoh | 7 |
| Foxo3 | Negative regulation of gene expression ( Insulin receptor signaling (Mammal) ) | inoh | 7 |
| Foxo3 | p73 transcription factor network | pid | 80 |
| Foxo3 | PI3 kinase pathway | panther | 38 |
| Foxo3 | Prolactin | netpath | 105 |
| Foxo3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Foxo3 | Signaling by NODAL | reactome | 19 |
| Foxo3 | Signaling events mediated by HDAC Class III | pid | 41 |
| Foxo3 | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| Foxo3 | TGF_beta_Receptor | netpath | 220 |
| Foxo3 | Trk receptor signaling mediated by PI3K and PLC-gamma | pid | 36 |
| Foxo3 | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Foxo3 | Chemokine signaling pathway | kegg | 187 |
| Foxo3 | Neurotrophin signaling pathway | kegg | 126 |
| Foxo3 | Endometrial cancer | kegg | 52 |
| Foxo3 | Non-small cell lung cancer | kegg | 54 |
| Foxo3 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| Foxo3 | Hs_Imatinib_and_Chronic_Myeloid_Leukemia_WP3640_89384 | wikipathways | 11 |
| Foxo3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Foxo3 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Foxo3 | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| Foxo3 | Hs_Energy_Metabolism_WP1541_91584 | wikipathways | 13 |
| Foxo3 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
| Foxo3 | Hs_IL-2_Signaling_Pathway_WP49_91243 | wikipathways | 33 |
| Foxo3 | Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 | wikipathways | 8 |
| Foxo3 | Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 | wikipathways | 80 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer