About Enhancer
| Enhancer ID: | E_03318 |
| Species: | Homo sapiens |
| Position : | chr11:2219531-2239062   |
| Year: | 2017 |
| Title: | Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Lung Cancer |
| PMID: | 27869826 |
| Tissue: | lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | HCC-15 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Disease-associated enhancer analysis |
| High Throughput Method: | ChIP-seq; 4C-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP |
About Target Gene
| Target gene : | IGF2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03293 | chr11:2218986-2222624 | colon | malignant cell | colorectal cancer |
| E_01649 | chr11:2223156-2236495 | colon | malignant cell | colorectal adenocarcinoma |
| E_03294 | chr11:2227598-2233058 | colon | malignant cell | colorectal cancer |
| E_01618 | chr11:2233643-2234213 | colon | epithelial cell | colorectal adenocarcinoma |
| E_01645 | chr11:2233643-2234213 | colon | malignant cell | colorectal adenocarcinoma |
| E_01646 | chr11:2233643-2234213 | colon | malignant cell | colorectal adenocarcinoma |
| E_03295 | chr11:2234046-2237062 | colon | malignant cell | colorectal cancer |
| E_03296 | chr11:2236031-2239626 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer