About Enhancer
| Enhancer ID: | E_03325 |
| Species: | Homo sapiens |
| Position : | chr2:233764355-233764676   |
| Year: | 2025 |
| Title: | Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 40301309 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | Primary hepatocytes |
| Cell Type: | hepatocyte |
| Cell Ontology ID: | CL:0000182 |
| Experiment Type: | Enhancer activity assay; Disease-variant functional analysis |
| High Throughput Method: | CAGE, ChIP-seq; CAGE; GWAS |
| Low Throughput Method: | Luciferase reporter assay |
About Target Gene
| Target gene : | UGT1A1 |
About TF
| TF name : | NR1I2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR1I2 | Nuclear Receptor transcription pathway | reactome | 51 |
| NR1I2 | Hs_Drug_Induction_of_Bile_Acid_Pathway_WP2289_88593 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer