About Enhancer
| Enhancer ID: | E_03325 |
| Species: | Mus musculus |
| Position : | chr15:98750000-98750480   |
| Year: | 2009 |
| Title: | Smad3 activates the Sox9-dependent transcription on chromatin |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chondrosarcoma |
| PMID: | 19041414 |
| MONDO: | MONDO:0005172 |
| Tissue: | Cartilage |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | SW1353 chondrosarcoma cells |
| CVCL ID: | CVCL_0543 |
| Cell Type: | chondrosarcoma cell |
| Cell Ontology ID: | CL:0000138 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA, In vitro transcription assay |
About Target Gene
| Target gene : | Col2A1 |
About TF
| TF name : | Sox9 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox9 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox9 | TGF_beta_Receptor | netpath | 220 |
| Sox9 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| Sox9 | Hs_Spinal_Cord_Injury_WP2431_87678 | wikipathways | 21 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer