About Enhancer
| Enhancer ID: | E_03335 |
| Species: | Mus musculus |
| Position : | chr6:122656000-122657000   |
| Year: | 2024 |
| Title: | Nucleosome fibre topology guides transcription factor binding to enhancers |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 39695228 |
| MONDO: | |
| Tissue: | Embryo |
| Tissue Ontology ID: | UBERON:0000922 |
| Cell Source: | Mouse embryonic fibroblasts |
| CVCL ID: | CVCL_0003 |
| Cell Type: | mouse embryonic fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer reporter assay |
| High Throughput Method: | snATAC-seq, snRNA-seq, Micro-C, MNase-seq, ChIP-seq |
| Low Throughput Method: | EMSA, immunoprecipitation, flow cytometry, immunostaining |
About Target Gene
| Target gene : | Nanog |
About TF
| TF name : | Oct4Sox2Klf4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| Sox2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| Sox2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Sox2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Sox2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| Sox2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| Sox2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Sox2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
| Klf4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| Klf4 | Synthesis, secretion, and deacylation of Ghrelin | reactome | 17 |
| Klf4 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| Klf4 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Klf4 | Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525 | wikipathways | 9 |
| Klf4 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| Klf4 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02898 | chr6:122620000-122660000 | Embryo | mouse embryonic stem cell | -- |
| E_02606 | chr6:122652768-122657768 | Embryo | mouse embryonic stem cell | -- |
| E_02907 | chr6:122655000-122657500 | Embryo | mouse embryonic stem cell | -- |
| E_03336 | chr6:122656000-122657000 | Embryo | embryonic stem cell | -- |
Expression of Target Genes for the Enhancer