About Enhancer
| Enhancer ID: | E_03343 |
| Species: | Homo sapiens |
| Position : | chr11:33396000-33396331   |
| Year: | 2019 |
| Title: | Sox7 negatively regulates prostate-specific membrane antigen (PSMA) expression through PSMA-enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 30488457 |
| MONDO: | MONDO:0008315 |
| Tissue: | prostate gland |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | LNCaP |
| CVCL ID: | CVCL_0395 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay; Enhancer activity assay; TF binding assay; In vivo functional validation |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, EMSA, RT-RT-qPCR; Luciferase reporter assay; EMSA; ChIP; In vivo phenotyping; Reporter assay |
About Target Gene
| Target gene : | FOLH1 |
About TF
| TF name : | SOX7 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX7 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX7 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer