About Enhancer
| Enhancer ID: | E_03345 |
| Species: | Mus musculus |
| Position : | chr16:20740332-20744432   |
| Year: | 2015 |
| Title: | MyoR modulates cardiac conduction by repressing Gata4 |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 25487574 |
| MONDO: | |
| Tissue: | Kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | COS7 |
| CVCL ID: | CVCL_0224 |
| Cell Type: | fibroblast-like cell |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | Microarray |
| Low Throughput Method: | Luciferase Reporter Assay, Transgenic Reporter Assay, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | Cx30.2 (Gjd3) |
About TF
| TF name : | Gata4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata4 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata4 | Notch-mediated HES/HEY network | pid | 48 |
| Gata4 | Physiological factors | reactome | 12 |
| Gata4 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| Gata4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| Gata4 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| Gata4 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| Gata4 | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer