About Enhancer
| Enhancer ID: | E_03355 |
| Species: | Homo sapiens |
| Position : | chr15:55288865-55289335   |
| Year: | 2023 |
| Title: | SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 37641131 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | MIA PaCa-2 |
| CVCL ID: | CVCL_0428 |
| Cell Type: | pancreatic carcinoma epithelial cell |
| Experiment Type: | Enhancer activity assay; Chromatin architectural-protein binding assay; Endogenous functional perturbation assay |
| High Throughput Method: | Public chromatin-conformation data; SMC3 ChIP-seq integration; TCGA methylation/expression analysis |
| Low Throughput Method: | SMC3 ChIP-qPCR; luciferase reporter assay; combined CRISPR/Cas9 enhancer targeting; RT-qPCR; Western blot |
About Target Gene
| Target gene : | RAB27A |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer