About Enhancer
| Enhancer ID: | E_03357 |
| Species: | Homo sapiens |
| Position : | chr9:27519197-27520919   |
| Year: | 2020 |
| Title: | A TGF-汕- and p63-Responsive Enhancer Regulates IFN-百 Expression in Human Keratinocytes. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32060133 |
| Tissue: | skin of body |
| Tissue Ontology ID: | UBERON:0002097 |
| Cell Source: | Normal human keratinocytes |
| Cell Type: | keratinocyte |
| Cell Ontology ID: | CL:0000312 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ENCODE epigenomic profiling |
| Low Throughput Method: | Luciferase reporter assay; enhancer deletion analysis; siRNA knockdown; ChIP-qPCR; qRT-PCR; Western blot |
About Target Gene
| Target gene : | IFNK |
About TF
| TF name : | TP63 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TP63 | Activation of PUMA and translocation to mitochondria | reactome | 8 |
| TP63 | Direct p53 effectors | pid | 141 |
| TP63 | Huntington disease | panther | 113 |
| TP63 | p53 pathway by glucose deprivation | panther | 21 |
| TP63 | p53 pathway | panther | 39 |
| TP63 | P53 pathway feedback loops 1 | panther | 6 |
| TP63 | p53 pathway feedback loops 2 | panther | 42 |
| TP63 | p73 transcription factor network | pid | 80 |
| TP63 | Regulation of TP53 Activity through Association with Co-factors | reactome | 14 |
| TP63 | TP53 Regulates Metabolic Genes | reactome | 85 |
| TP63 | TP53 Regulates Transcription of Caspase Activators and Caspases | reactome | 12 |
| TP63 | TP53 Regulates Transcription of Death Receptors and Ligands | reactome | 12 |
| TP63 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | reactome | 19 |
| TP63 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | reactome | 14 |
| TP63 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| TP63 | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
| TP63 | Hs_Focal_Adhesion_WP306_80308 | wikipathways | 26 |
| TP63 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
| TP63 | Hs_Urea_cycle_and_metabolism_of_amino_groups_WP497_72142 | wikipathways | 8 |
| TP63 | Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473 | wikipathways | 5 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03358 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03359 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03360 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03386 | chr9:27519749-27519900 | zone of skin | keratinocyte | NA |
| E_03387 | chr9:27520189-27520340 | zone of skin | keratinocyte | NA |
Expression of Target Genes for the Enhancer