About Enhancer
| Enhancer ID: | E_03360 |
| Species: | Homo sapiens |
| Position : | chr9:27519197-27520919   |
| Year: | 2020 |
| Title: | A TGF-汕- and p63-Responsive Enhancer Regulates IFN-百 Expression in Human Keratinocytes. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 32060133 |
| Tissue: | skin of body |
| Tissue Ontology ID: | UBERON:0002097 |
| Cell Source: | Normal human keratinocytes |
| Cell Type: | keratinocyte |
| Cell Ontology ID: | CL:0000312 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ENCODE epigenomic profiling |
| Low Throughput Method: | Luciferase reporter assay; EMSA; siRNA knockdown; ChIP-qPCR; qRT-PCR; Western blot |
About Target Gene
| Target gene : | IFNK |
About TF
| TF name : | TFAP2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TFAP2C | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03357 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03358 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03359 | chr9:27519197-27520919 | skin of body | keratinocyte | NA |
| E_03386 | chr9:27519749-27519900 | zone of skin | keratinocyte | NA |
| E_03387 | chr9:27520189-27520340 | zone of skin | keratinocyte | NA |
Expression of Target Genes for the Enhancer