About Enhancer
| Enhancer ID: | E_03366 |
| Species: | Homo sapiens |
| Position : | chr1:183149939-183150336   |
| Year: | 2014 |
| Title: | Identification of TNF-ζ±-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 24990076 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Caco-2 |
| CVCL ID: | CVCL_0025 |
| Cell Type: | intestinal epithelial cell |
| Cell Ontology ID: | CL:0002563 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay |
| High Throughput Method: | CAGE; ENCODE ChIP-seq data integration |
| Low Throughput Method: | Luciferase Reporter Assay; TNF-alpha stimulation; RELA/NFKB2 co-transfection; NF-kB inhibition; RT-qPCR; Western blot |
About Target Gene
| Target gene : | LAMC2 |
About TF
| TF name : | NFKB2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFKB2 | Alternative NF-kappaB pathway | pid | 6 |
| NFKB2 | Apoptosis signaling pathway | panther | 104 |
| NFKB2 | Dectin-1 mediated noncanonical NF-kB signaling | reactome | 61 |
| NFKB2 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | reactome | 13 |
| NFKB2 | IkBA variant leads to EDA-ID | reactome | 7 |
| NFKB2 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) | reactome | 8 |
| NFKB2 | IL12-mediated signaling events | pid | 62 |
| NFKB2 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| NFKB2 | Interleukin-1 processing | reactome | 7 |
| NFKB2 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | smpdb | 37 |
| NFKB2 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | smpdb | 38 |
| NFKB2 | NIK-->noncanonical NF-kB signaling | reactome | 58 |
| NFKB2 | RANKL | netpath | 84 |
| NFKB2 | RIP-mediated NFkB activation via ZBP1 | reactome | 21 |
| NFKB2 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex | reactome | 26 |
| NFKB2 | TNFalpha | netpath | 274 |
| NFKB2 | TRAF6 mediated NF-kB activation | reactome | 24 |
| NFKB2 | TSLP | netpath | 24 |
| NFKB2 | TWEAK | netpath | 35 |
| NFKB2 | MAPK signaling pathway | kegg | 264 |
| NFKB2 | Pathways in cancer | kegg | 321 |
| NFKB2 | Hs_TNF_alpha_Signaling_Pathway_WP231_89895 | wikipathways | 61 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
Expression of Target Genes for the Enhancer