About Enhancer
| Enhancer ID: | E_03368 |
| Species: | Homo sapiens |
| Position : | chr10:43569015-43569494   |
| Year: | 2011 |
| Title: | Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | neuroblastoma |
| PMID: | 20952403 |
| MONDO: | MONDO:0005072 |
| Cell Source: | SK-N-BE |
| Cell Type: | neuroblastoma cell line |
| Experiment Type: | Enhancer activity assay; TF binding assay; DNA methylation assay; Functional perturbation assay |
| High Throughput Method: | DNA methylation profiling |
| Low Throughput Method: | Luciferase reporter assay; ChIP-qPCR; bisulfite sequencing; Sequenom MassARRAY; pyrosequencing; qRT-PCR; siRNA knockdown |
About Target Gene
| Target gene : | RET |
About TF
| TF name : | RARA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| RARA | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| RARA | FSH | netpath | 44 |
| RARA | IL3 | netpath | 84 |
| RARA | Nuclear Receptor transcription pathway | reactome | 51 |
| RARA | Retinoic acid receptors-mediated signaling | pid | 30 |
| RARA | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| RARA | Signaling by Retinoic Acid | reactome | 20 |
| RARA | Pathways in cancer | kegg | 321 |
| RARA | Acute myeloid leukemia | kegg | 53 |
| RARA | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03708 | chr10:43568986-43571244 | peripheral nervous system | neural crest derived neuroblast | Hirschsprung disease |
| E_03815 | chr10:43568986-43571244 | blood / hematopoietic system | NA | Hirschsprung Disease |
| E_03816 | chr10:43568986-43571244 | blood / hematopoietic system | NA | Hirschsprung Disease |
| E_03400 | chr10:43569045-43569456 | NA | malignant cell | NA |
| E_03401 | chr10:43569045-43569456 | NA | malignant cell | NA |
| E_03398 | chr10:43569296-43572684 | NA | malignant cell | NA |
| E_03399 | chr10:43569296-43572684 | NA | malignant cell | NA |
Expression of Target Genes for the Enhancer