About Enhancer
| Enhancer ID: | E_03370 |
| Species: | Homo sapiens |
| Position : | chr11:5225000-5226000   |
| Year: | 2022 |
| Title: | Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic myeloid leukemia |
| PMID: | 35849129 |
| MONDO: | MONDO:0011996 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K-562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | CUT&RUN |
| Low Throughput Method: | CRISPR Knockout; CRISPRi; RT-RT-qPCR, 3C-RT-qPCR; Western blot |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03369 | chr11:5225000-5226000 | uterine cervix | malignant cell | cervical cancer |
| E_03374 | chr11:5225000-5226000 | bone element | osteosarcoma cell | osteosarcoma |
| E_03376 | chr11:5225000-5226000 | kidney | embryonic kidney cell | NA |
| E_04228 | chr11:5225440-5225500 | bone marrow | hematopoietic stem cell | beta-thalassemia |
Expression of Target Genes for the Enhancer