About Enhancer
| Enhancer ID: | E_03370 |
| Species: | Mus musculus |
| Position : | chr12:31875800-31876373   |
| Year: | 2019 |
| Title: | Runx1 and ROR??t Cooperate to Upregulate IL-22 Expression in Th Cells through Its Distal Enhancer |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 31028121 |
| MONDO: | |
| Tissue: | Spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | CD4+ T cells |
| CVCL ID: | |
| Cell Type: | CD4-positive T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | |
| Low Throughput Method: | Luciferase Reporter Assay, 3C-seq, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | Il22 |
About TF
| TF name : | Runx1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Runx1 | AndrogenReceptor | netpath | 167 |
| Runx1 | Organic cation transport | reactome | 9 |
| Runx1 | RANKL | netpath | 84 |
| Runx1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Runx1 | TGF_beta_Receptor | netpath | 220 |
| Runx1 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
| Runx1 | Pathways in cancer | kegg | 321 |
| Runx1 | Chronic myeloid leukemia | kegg | 69 |
| Runx1 | Acute myeloid leukemia | kegg | 53 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
No overlapping enhancers found in mm10 at this locus.
Expression of Target Genes for the Enhancer