About Enhancer
| Enhancer ID: | E_03399 |
| Species: | Homo sapiens |
| Position : | chr10:43569296-43572684   |
| Year: | 2011 |
| Title: | Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 20952403 |
| Cell Source: | SK-N-BE |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; ChIP-qPCR/ChIP; RT-qPCR/qPCR |
About Target Gene
| Target gene : | RET |
About TF
| TF name : | EZH2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| EZH2 | Oxidative Stress Induced Senescence | reactome | 120 |
| EZH2 | PKMTs methylate histone lysines | reactome | 64 |
| EZH2 | PRC2 methylates histones and DNA | reactome | 71 |
| EZH2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| EZH2 | Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 | wikipathways | 15 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03708 | chr10:43568986-43571244 | peripheral nervous system | neural crest derived neuroblast | Hirschsprung disease |
| E_03815 | chr10:43568986-43571244 | blood / hematopoietic system | NA | Hirschsprung Disease |
| E_03816 | chr10:43568986-43571244 | blood / hematopoietic system | NA | Hirschsprung Disease |
| E_03368 | chr10:43569015-43569494 | NA | neuroblastoma cell line | neuroblastoma |
| E_03400 | chr10:43569045-43569456 | NA | malignant cell | NA |
| E_03401 | chr10:43569045-43569456 | NA | malignant cell | NA |
| E_03398 | chr10:43569296-43572684 | NA | malignant cell | NA |
| E_03709 | chr10:43571244-43572713 | peripheral nervous system | neural crest derived neuroblast | Hirschsprung disease |
| E_03817 | chr10:43571244-43572713 | blood / hematopoietic system | NA | Hirschsprung Disease |
| E_03818 | chr10:43571244-43572713 | blood / hematopoietic system | NA | Hirschsprung Disease |
Expression of Target Genes for the Enhancer