About Enhancer
| Enhancer ID: | E_03403 |
| Species: | Mus musculus |
| Position : | chr7:35912057-35912683   |
| Year: | 2019 |
| Title: | HoxA9 binds and represses the Cebpa +8 kb enhancer. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 31120998 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | 32Dcl3 |
| CVCL ID: | CVCL_0119 |
| Cell Type: | myeloid progenitor cell |
| Experiment Type: | Enhancer activity assay |
| High Throughput Method: | HoxA9 ChIP-seq; ChIP-seq |
| Low Throughput Method: | C/EBPalpha-binding-site mutagenesis; luciferase reporter assay |
About Target Gene
| Target gene : | Cebpa |
About TF
| TF name : | Cebpa |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Cebpa | AndrogenReceptor | netpath | 167 |
| Cebpa | C-MYB transcription factor network | pid | 87 |
| Cebpa | E2F transcription factor network | pid | 77 |
| Cebpa | EGFR1 | netpath | 475 |
| Cebpa | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| Cebpa | IL4 | netpath | 75 |
| Cebpa | Regulation of Androgen receptor activity | pid | 54 |
| Cebpa | Regulation of retinoblastoma protein | pid | 67 |
| Cebpa | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| Cebpa | Validated targets of C-MYC transcriptional repression | pid | 63 |
| Cebpa | Pathways in cancer | kegg | 321 |
| Cebpa | Acute myeloid leukemia | kegg | 53 |
| Cebpa | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| Cebpa | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| Cebpa | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| Cebpa | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03389 | chr7:35912057-35912683 | bone marrow | myeloid progenitor cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer