About Enhancer
| Enhancer ID: | E_03433 |
| Species: | Mus musculus |
| Position : | chr15:63255515-63256347   |
| Year: | 2019 |
| Title: | GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 31519704 |
| MONDO: | MONDO:0004963 |
| Tissue: | thymus |
| Tissue Ontology ID: | UBERON:0002370 |
| Cell Source: | N-Me GATA-site mutant mouse DN3 thymocytes |
| Cell Type: | double negative thymocyte |
| Cell Ontology ID: | CL:0002489 |
| Experiment Type: | Endogenous TF-site perturbation; enhancer accessibility assay; enhancer-promoter interaction assay |
| High Throughput Method: | ATAC-seq; ChIP-seq; 4C-seq |
| Low Throughput Method: | Endogenous GATA-site mutation; flow cytometry; ChIP-qPCR; DNA FISH; nucleosome occupancy analysis; RT-qPCR |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | Gata3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata3 | C-MYB transcription factor network | pid | 87 |
| Gata3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| Gata3 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata3 | Glucocorticoid receptor regulatory network | pid | 85 |
| Gata3 | IL27-mediated signaling events | pid | 26 |
| Gata3 | Notch signaling pathway | pid | 58 |
| Gata3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| Gata3 | Hs_Endochondral_Ossification_WP474_87977 | wikipathways | 43 |
| Gata3 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer