About Enhancer
| Enhancer ID: | E_03453 |
| Species: | Homo sapiens |
| Position : | chr6:138229810-138230149   |
| Year: | 2013 |
| Title: | An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Systemic lupus erythematosus |
| PMID: | 24039598 |
| MONDO: | MONDO:0007915 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | EBV-transformed lymphoblastoid cells from risk and non-risk donors |
| Cell Type: | B lymphoblastoid cell / monocyte-like cell |
| Experiment Type: | Enhancer activity; chromatin organizer dependency; enhancer-promoter looping |
| Low Throughput Method: | EMSA; DNA-affinity pull-down and mass spectrometry; luciferase reporter assay; ChIP-PCR; 3C; SATB1 shRNA knockdown; RT-qPCR |
About Target Gene
| Target gene : | TNFAIP3 |
About TF
| TF name : | SATB1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SATB1 | Apoptotic cleavage of cellular proteins | reactome | 18 |
| SATB1 | Caspase Cascade in Apoptosis | pid | 57 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03682 | chr6:138226720-138233280 | blood / hematopoietic system | B cell | Autoimmune Diseases |
| E_03443 | chr6:138229810-138230149 | bone marrow | malignant cell | systemic lupus erythematosus |
| E_03450 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03451 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03452 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03526 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03527 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03528 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03529 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03534 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03535 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03536 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03537 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
Expression of Target Genes for the Enhancer