About Enhancer
| Enhancer ID: | E_03487 |
| Species: | Homo sapiens |
| Position : | chr8:130580000-130581100   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | CD34+ HSPCs |
| CVCL ID: | |
| Cell Type: | CD34-positive hematopoietic stem cell |
| Cell Ontology ID: | CL:0001029 |
| Experiment Type: | TF binding assay, Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, 4C-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Western blot, FISH, Flow Cytometry |
About Target Gene
| Target gene : | EVI1 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00194 | chr8:130475000-130775000 | Peripheral Blood | acute monocytic leukemia cell | acute monocytic leukemia |
| E_00195 | chr8:130475000-130775000 | Prostate | prostate carcinoma cell | prostate cancer |
| E_03485 | chr8:130580000-130581100 | Peripheral Blood | K562 erythroleukemia cell | acute myeloid leukemia |
| E_03486 | chr8:130580000-130581100 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer