About Enhancer
| Enhancer ID: | E_03496 |
| Species: | Mus musculus |
| Position : | chr11:32168783-32169689   |
| Year: | 2007 |
| Title: | Tissue-specific histone modification and transcription factor binding in alpha globin gene expression. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 17715390 |
| Tissue: | spleen |
| Tissue Ontology ID: | UBERON:0002106 |
| Cell Source: | Primary erythroid cells from humanized mouse |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | TF binding assay; Chromatin modification assay; In vivo functional validation |
| Low Throughput Method: | ChIP-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | Hba-a1 |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
18 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_00120 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00121 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00122 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00123 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00124 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00125 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00126 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00127 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00128 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00129 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00130 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00131 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_03323 | chr11:32168783-32169689 | liver | erythroid cell | NA |
| E_03497 | chr11:32168783-32169689 | spleen | erythroblast | NA |
| E_03498 | chr11:32168783-32169689 | spleen | erythroblast | NA |
| E_03499 | chr11:32168783-32169689 | spleen | erythroblast | NA |
Expression of Target Genes for the Enhancer