About Enhancer
| Enhancer ID: | E_03504 |
| Species: | Homo sapiens |
| Position : | chr12:11718965-11902194   |
| Year: | 2024 |
| Title: | ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | skin melanoma |
| PMID: | 38356460 |
| MONDO: | MONDO:0005105 |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | 501MEL |
| CVCL ID: | CVCL_4633 |
| Cell Type: | melanoma cell |
| Cell Ontology ID: | CL:0002573 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | Hi-C, RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | ETV6 |
About TF
| TF name : | PAX5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX5 | C-MYB transcription factor network | pid | 87 |
| PAX5 | ID | netpath | 38 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer