About Enhancer
| Enhancer ID: | E_03506 |
| Species: | Homo sapiens |
| Position : | chr6:30904342-30904788   |
| Year: | 2016 |
| Title: | A New Class of Temporarily Phenotypic Enhancers Identified by CRISPR/Cas9 Mediated Genetic Screening |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | B-cell acute lymphoblastic leukemia |
| PMID: | 26813977 |
| MONDO: | MONDO:0004945 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary ALL cells |
| CVCL ID: | |
| Cell Type: | B lymphoblast |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Functional perturbation assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 4C-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, Luciferase Reporter Assay, RT-RT-qPCR |
About TF
| TF name : | POU5F1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| POU5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| POU5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| POU5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01208 | chr6:30904342-30904788 | Inner cell mass | embryonic stem cell | -- |
Expression of Target Genes for the Enhancer