About Enhancer
| Enhancer ID: | E_03516 |
| Species: | Homo sapiens |
| Position : | chr2:65633710-65634058   |
| Year: | 2023 |
| Title: | Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | rheumatoid arthritis |
| PMID: | 36924774 |
| MONDO: | MONDO:0005280 |
| Tissue: | Synovial tissue |
| Tissue Ontology ID: | UBERON:0002407 |
| Cell Source: | MH7A |
| CVCL ID: | CVCL_0427 |
| Cell Type: | synovial fibroblast |
| Cell Ontology ID: | CL:0000057 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | Hi-C, ATAC-seq, ChIP-seq |
| Low Throughput Method: | CRISPR knockout, Luciferase Reporter Assay, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | SPRED2 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03493 | chr2:65633710-65634058 | Embryonic Kidney | embryonic kidney cell | -- |
Expression of Target Genes for the Enhancer