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Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_03517
Species: Homo sapiens
Position : chr1:47644434-47659486
Year: 2022
Title: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
Genome Build: hg19
Enhancer Type: Enhancer
Condition: Disease
Disease Name: colorectal cancer
PMID:  36253360
MONDO: MONDO:0005176
Tissue: Colon
Tissue Ontology ID: UBERON:0001155
Cell Source: HT29
CVCL ID: CVCL_0320
Cell Type: colorectal carcinoma cell
Cell Ontology ID: CL:0000066
Experiment Type: Super enhancer activity assay, Functional perturbation assay
High Throughput Method: ChIP-seq, ATAC-seq, RNA-seq
Low Throughput Method: CRISPRi, Luciferase Reporter Assay
About Target Gene
Target gene : PDZK1IP1
About TF
TF name : RELA
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
RELA Activation of NF-kappaB in B cells reactome 66
RELA Angiopoietin receptor Tie2-mediated signaling pid 50
RELA Apoptosis signaling pathway panther 104
RELA Atypical NF-kappaB pathway pid 14
RELA BCR netpath 161
RELA BCR signaling pathway pid 70
RELA Canonical NF-kappaB pathway pid 24
RELA CD209 (DC-SIGN) signaling reactome 21
RELA CD40/CD40L signaling pid 36
RELA Ceramide signaling pathway pid 49
RELA CLEC7A (Dectin-1) signaling reactome 78
RELA CLEC7A/inflammasome pathway reactome 6
RELA Dectin-1 mediated noncanonical NF-kB signaling reactome 61
RELA DEx/H-box helicases activate type I IFN and inflammatory cytokines production reactome 13
RELA Downstream TCR signaling reactome 101
RELA EGFR1 netpath 475
RELA Fc-epsilon receptor I signaling in mast cells pid 64
RELA FCERI mediated NF-kB activation reactome 88
RELA FSH netpath 44
RELA Glucocorticoid receptor regulatory network pid 85
RELA HIV-1 Nef: Negative effector of Fas and TNF-alpha pid 33
RELA IkBA variant leads to EDA-ID reactome 7
RELA IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) reactome 8
RELA IKK-NF-kappaB cascade ( B cell receptor signaling ) inoh 8
RELA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 8
RELA IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) inoh 8
RELA IKK-NFkB cascade ( TNFR1 signaling pathway ) inoh 11
RELA IL1-mediated signaling events pid 34
RELA IL1 netpath 69
RELA IL12-mediated signaling events pid 62
RELA IL2 netpath 81
RELA IL2 signaling events mediated by PI3K pid 38
RELA IL23-mediated signaling events pid 37
RELA IL4 netpath 75
RELA Inflammation mediated by chemokine and cytokine signaling pathway panther 189
RELA Interleukin-1 processing reactome 7
RELA KitReceptor netpath 104
RELA Leptin netpath 98
RELA LPA receptor mediated events pid 65
RELA NF-kB is activated and signals survival reactome 13
RELA NF-kB signaling ( Toll-like receptor signaling pathway (trough NF-kappaB) ) inoh 12
RELA Notch netpath 76
RELA Osteopontin-mediated events pid 32
RELA p73 transcription factor network pid 80
RELA Prolactin netpath 105
RELA RANKL netpath 84
RELA Regulated proteolysis of p75NTR reactome 10
RELA RIP-mediated NFkB activation via ZBP1 reactome 21
RELA Senescence-Associated Secretory Phenotype (SASP) reactome 108
RELA Signaling events mediated by HDAC Class I pid 89
RELA T cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) ( CD4 T cell receptor signaling (NF-kB cascade) ) inoh 30
RELA T cell receptor signaling pathway ( CD4 T cell receptor signaling ) inoh 33
RELA TAK1 activates NFkB by phosphorylation and activation of IKKs complex reactome 26
RELA TCR netpath 261
RELA TNF receptor signaling pathway pid 46
RELA TNFalpha netpath 274
RELA TRAF6 mediated NF-kB activation reactome 24
RELA Transcriptional regulation of white adipocyte differentiation reactome 79
RELA TSH netpath 82
RELA TSLP netpath 24
RELA TWEAK netpath 35
RELA MAPK signaling pathway kegg 264
RELA Chemokine signaling pathway kegg 187
RELA Apoptosis kegg 88
RELA Toll-like receptor signaling pathway kegg 100
RELA NOD-like receptor signaling pathway kegg 60
RELA RIG-I-like receptor signaling pathway kegg 71
RELA Cytosolic DNA-sensing pathway kegg 56
RELA T cell receptor signaling pathway kegg 105
RELA B cell receptor signaling pathway kegg 70
RELA Neurotrophin signaling pathway kegg 126
RELA Adipocytokine signaling pathway kegg 65
RELA Epithelial cell signaling in Helicobacter pylori infection kegg 67
RELA Shigellosis kegg 60
RELA Leishmaniasis kegg 71
RELA Chagas disease kegg 103
RELA Toxoplasmosis kegg 131
RELA Amoebiasis kegg 103
RELA Hepatitis C kegg 134
RELA Pathways in cancer kegg 321
RELA Pancreatic cancer kegg 70
RELA Prostate cancer kegg 85
RELA Chronic myeloid leukemia kegg 69
RELA Acute myeloid leukemia kegg 53
RELA Small cell lung cancer kegg 83
RELA Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 wikipathways 41
RELA Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035 wikipathways 37
RELA Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 wikipathways 17
RELA Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
RELA Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
RELA Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910 wikipathways 27
RELA Hs_p38_MAPK_Signaling_Pathway_WP400_72084 wikipathways 28
RELA Hs_IL17_signaling_pathway_WP2112_89838 wikipathways 20
RELA Hs_Prolactin_Signaling_Pathway_WP2037_90015 wikipathways 52
RELA Hs_AGE-RAGE_pathway_WP2324_89798 wikipathways 27
RELA Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80
RELA Hs_IL-1_signaling_pathway_WP195_89932 wikipathways 34
RELA Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 wikipathways 26
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer