About Enhancer
| Enhancer ID: | E_03523 |
| Species: | Homo sapiens |
| Position : | chr7:54932020-54934020   |
| Year: | 2019 |
| Title: | Functional Enhancers Shape Extrachromosomal Oncogene Amplifications |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 31761532 |
| MONDO: | MONDO:0005142 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | G361 glioblastoma |
| CVCL ID: | CVCL_1220 |
| Cell Type: | glioblastoma cell |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq, 4C-seq, CRISPRi screen |
| Low Throughput Method: | CRISPRi, RT-RT-qPCR, Alamar Blue Assay |
About Target Gene
| Target gene : | EGFR |
About TF
| TF name : | SOX2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX2 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX2 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| SOX2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| SOX2 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| SOX2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| SOX2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| SOX2 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
| SOX2 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| SOX2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00219 | chr7:54932020-54934020 | Brain | glioblastoma cell | glioblastoma |
Expression of Target Genes for the Enhancer