About Enhancer
| Enhancer ID: | E_03532 |
| Species: | Homo sapiens |
| Position : | chr3:128322411-128323124   |
| Year: | 2021 |
| Title: | Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| PMID: | 33911178 |
| MONDO: | MONDO:0018435 |
| Tissue: | Bone marrow / hematopoietic system |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MUTZ-3 |
| CVCL ID: | CVCL_1433 |
| Cell Type: | myeloid leukemia cell |
| Experiment Type: | TF-site functional validation; enhancer complex characterization; enhancer-promoter interaction |
| High Throughput Method: | ChIP-seq; ChIP-SICAP quantitative mass spectrometry; RNA-seq; 4C-seq |
| Low Throughput Method: | Luciferase enhancer truncation; CEBPA-binding-site mutagenesis; CEBPA knockdown; ChIP-qPCR; DNA pull-down; western blotting; co-immunoprecipitation; qPCR |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | CEBPA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CEBPA | AndrogenReceptor | netpath | 167 |
| CEBPA | C-MYB transcription factor network | pid | 87 |
| CEBPA | E2F transcription factor network | pid | 77 |
| CEBPA | EGFR1 | netpath | 475 |
| CEBPA | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| CEBPA | IL4 | netpath | 75 |
| CEBPA | Regulation of Androgen receptor activity | pid | 54 |
| CEBPA | Regulation of retinoblastoma protein | pid | 67 |
| CEBPA | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| CEBPA | Validated targets of C-MYC transcriptional repression | pid | 63 |
| CEBPA | Pathways in cancer | kegg | 321 |
| CEBPA | Acute myeloid leukemia | kegg | 53 |
| CEBPA | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 |
| CEBPA | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 |
| CEBPA | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| CEBPA | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
41 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03426 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03427 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03428 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03429 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03430 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03431 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03504 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03505 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03506 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03507 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03508 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03509 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03510 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03511 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03512 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03513 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03514 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03515 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03516 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03517 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03518 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03519 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03520 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03521 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03522 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03523 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03524 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_01351 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [inv(3)(q21;q26.2)/t(3;3)(q21;q26.2)] |
| E_01372 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01373 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01382 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01383 | chr3:128322411-128323124 | bone marrow | malignant cell | acute myeloid leukemia |
| E_01394 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01395 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01396 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01397 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01403 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01404 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_03530 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03531 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03533 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
Expression of Target Genes for the Enhancer