About Enhancer
| Enhancer ID: | E_03536 |
| Species: | Homo sapiens |
| Position : | chr6:138229810-138230149   |
| Year: | 2013 |
| Title: | An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Systemic lupus erythematosus |
| PMID: | 24039598 |
| MONDO: | MONDO:0007915 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | HEK293T |
| CVCL ID: | CVCL_0063 |
| Cell Type: | B lymphoblastoid cell / monocyte-like cell |
| Experiment Type: | Enhancer activity; TF binding; long-range enhancer-promoter looping |
| Low Throughput Method: | EMSA; DNA-affinity pull-down and mass spectrometry; luciferase reporter assay; ChIP-PCR; 3C; stimulation assays; RT-qPCR |
About Target Gene
| Target gene : | TNFAIP3 |
About TF
| TF name : | REL |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| REL | Activation of NF-kappaB in B cells | reactome | 66 |
| REL | Apoptosis signaling pathway | panther | 104 |
| REL | Atypical NF-kappaB pathway | pid | 14 |
| REL | BCR | netpath | 161 |
| REL | IL1 | netpath | 69 |
| REL | Leptin | netpath | 98 |
| REL | RANKL | netpath | 84 |
| REL | Regulation of Androgen receptor activity | pid | 54 |
| REL | TCR | netpath | 261 |
| REL | TNFalpha | netpath | 274 |
| REL | Hs_TNF_alpha_Signaling_Pathway_WP231_89895 | wikipathways | 61 |
| REL | Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 | wikipathways | 60 |
| REL | Hs_IL-1_signaling_pathway_WP195_89932 | wikipathways | 34 |
| REL | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03682 | chr6:138226720-138233280 | blood / hematopoietic system | B cell | Autoimmune Diseases |
| E_03443 | chr6:138229810-138230149 | bone marrow | malignant cell | systemic lupus erythematosus |
| E_03450 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03451 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03452 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03453 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03526 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03527 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03528 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03529 | chr6:138229810-138230149 | blood | monocyte | Systemic lupus erythematosus |
| E_03534 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03535 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
| E_03537 | chr6:138229810-138230149 | blood | B lymphoblastoid cell / monocyte-like cell | Systemic lupus erythematosus |
Expression of Target Genes for the Enhancer