About Enhancer
| Enhancer ID: | E_03538 |
| Species: | Mus musculus |
| Position : | chr15:63611116-63736746   |
| Year: | 2018 |
| Title: | A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 29342133 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | mouse MLL-AF9 leukemia and HSC/progenitor models |
| Cell Type: | leukemic hematopoietic stem/progenitor cell |
| Experiment Type: | Enhancer-cluster perturbation in normal and leukemic hematopoietic hierarchies |
| High Throughput Method: | ATAC-seq; H3K27ac/TF ChIP-seq; human AML accessibility/transcriptomic analysis |
| Low Throughput Method: | BENC deletion; Myc expression; flow cytometry; transplantation; MLL-AF9 leukemia maintenance assays |
About Target Gene
| Target gene : | Myc |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm10)
10 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03434 | chr15:63611116-63611556 | bone marrow | hematopoietic stem cell | NA |
| E_03435 | chr15:63616791-63618232 | bone marrow | hematopoietic stem cell | NA |
| E_03503 | chr15:63648126-63648667 | bone marrow | hematopoietic stem cell | NA |
| E_03436 | chr15:63657837-63659699 | bone marrow | hematopoietic stem cell | NA |
| E_03437 | chr15:63665359-63665959 | bone marrow | hematopoietic stem cell | NA |
| E_03438 | chr15:63678942-63679359 | bone marrow | hematopoietic stem cell | NA |
| E_03439 | chr15:63704706-63705184 | bone marrow | hematopoietic stem cell | NA |
| E_03440 | chr15:63709542-63709926 | bone marrow | hematopoietic stem cell | NA |
| E_03557 | chr15:63714919-63952099 | blood / hematopoietic system | NA | Leukaemia |
| E_03441 | chr15:63736276-63736746 | bone marrow | hematopoietic stem cell | NA |
Expression of Target Genes for the Enhancer