About Enhancer
| Enhancer ID: | E_03566 |
| Species: | Homo sapiens |
| Position : | chr16:30669227-30670310   |
| Year: | 2024 |
| Title: | Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 39143563 |
| Tissue: | neural tissue |
| Tissue Ontology ID: | UBERON:0003714 |
| Cell Source: | hESC-derived NPCs |
| Cell Type: | neural progenitor cell |
| Cell Ontology ID: | CL:0011020 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay; Enhancer activity assay; Disease-variant functional analysis |
| High Throughput Method: | RNA-seq, ChIP-seq, ATAC-seq; MPRA |
| Low Throughput Method: | TF overexpression assay, RT-RT-qPCR, FIMO motif analysis, permutation test; Reporter assay |
About Target Gene
| Target gene : | PHKG2 |
About TF
| TF name : | PAX6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX6 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| PAX6 | CDC42 signaling events | pid | 71 |
| PAX6 | Regulation of gene expression in beta cells | reactome | 17 |
| PAX6 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
| PAX6 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) | reactome | 13 |
| PAX6 | Maturity onset diabetes of the young | kegg | 25 |
| PAX6 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer